Chances are, you may have already heard about resveratrol – it has been causing a lot of buzz in the medical and research circles (and with wine lovers alike) since preliminary studies were published in the mid-90s. In a nutshell, resveratrol is the stilbenoid (a natural phenol) found in the skin of red wine grapes, berries, and senna, that plays a key role in wine’s health benefits (Artero et. al, 2015; Tome-Carneiro et. al, 2012).
The early commercial interest in resveratrol’s probable therapeutic effects had wine enthusiasts misleading people that wine was completely healthy. To add to this, some companies started selling juice extracts containing resveratrol as the ultimate antioxidant. This hype attracted several criticisms from different experts in the medical field. At that time, research were only done in the lab on non-human models with no idea about resveratrol’s absorption and clearance, and in 2012 one of the researchers doing work on resveratrol retracted his reports on the compound’s benefial properties due to research misconduct (Barrett, 2014).
More recent studies, however, are now dispelling the controversies about resveratrol. It has previously been thought that because the blood level of the chemical drops too fast after metabolism, it would be impossible to use it in clinical trials. However, a 2013 study showed that after resveratrol has been metabolized into resveratrol sulfates, it is broken down into resveratrol again and achieves higher concentration in the cells (Patel et. al, 2013). This study laid the foundation for future clinical trials. In 2015, research results of a phase II clinical trial of a high dose pure synthetic resveratrol confirmed that resveratrol activates sirtuins (proteins linked to better health and increased longevity) and this activation decreases inflammation in Alzheimer’s (Moussa et al, 2015). Other laboratory studies have been confirming that resveratrol is also effective against other kinds of inflammation – bacteria in otitis media, COPD, and Haemophilus influenzae infection (Li et. al, 2016).
To sum up, resveratrol, as a polyphenol, is an antioxidant with potent anti-inflammatory effects, useful in its metabolized form (sulfate) and proven to work in human clinical trials. Two decades ago, we were all laughing at “quacky” antioxidant dietary supplements. Over the years, however, studies have been establishing that vitamin supplements – mainly antioxidants like vitamin C, vitamin E, and beta-carotene, do help slow the aging process and improve the health of older adults (Sadowski et. al, 2014). A decade ago and even just two years ago, we have been questioning resveratrol as a therapeutic molecule. Now, we have scientific evidence to believe it to be. Bear in mind, though, that any benefits from resveratrol does not come from drinking red wine. You also have to consider the well-established fact that drinking any type of alcohol increases the risk of developing cancer (Williams, 2013).
To give you the benefits of resveratrol without the cancer, Health Funatics’ proprietary Exotic Juice Complex combines anti-oxidants from exotic fruits including mangosteen, pomegranate, goji, acai, berries, and sprinkled with resveratrol. It is basically wine in a capsule minus the alcohol and more of the good stuff.
To learn more about resveratrol and ongoing researches, you can click on the references attached to this article. To learn more about our product or how to purchase it, click here.
Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence, K.R. Patel et al, Science Translational Medicine, 2013.
A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol, Nature, DOI: 10.1038/nature14028
Resveratrol activates CSF Sirtuin1/Matrix Mettaloproteinase-9 and regulates inflammation in Alzheimer’s disease, Alzheimer’s Association International Conference 2016.
A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease, R.S. Turner et al, Neurology, DOI: http://dx.doi.org/10.1212/WNL.0000000000002035.
Resveratrol suppresses NTHi-induced inflammation via up-regulation of the negative regulator MyD88 short, JD Li et al, Scientific Reports, DOI: http://dx.doi.org/10.1038/srep34445
Resveratrol, Linus Pauling Institute Micronutrient Information Center, http://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/resveratrol. This link leads to a website provided by the Linus Pauling Institute at Oregon State University. Health Funatics is not affiliated or endorsed by the Linus Pauling Institute or Oregon State University.
Resveratrol: don’t buy the hype, S. Barrett, Quackwatch, http://www.quackwatch.com/01QuackeryRelatedTopics/DSH/resveratrol.html.